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KMID : 0363620080290030144
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 3 p.144 ~ p.154
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Effects of Lycii Fructus on the Ovariectomized Osteoporosis of Rats
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Koo Yong-Mo
Sohn Young-Joo
Choi Hyun
Kim Sung-Hoon
Kim Eun-Young
Lee Hyun-Sam
Jung Hyuk-Sang
Sohn Nak-Won
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Abstract
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Objectives: Osteoporosis is one of the most common metabolic bone disorders in the menopausal stage, a disease signified by decrease of bone mass. The purpose of this study was to learn how Lycii Fructus influences SD rats with osteoporosis caused by the removal of the ovaries.
Methods: After the removal of the ovaries from 24 female Sprague-Dawley rats, they were divided into a normal group, a control group, and a Lycii Fructus (25mg/100g) administration group. After 8 weeks, the rats were sacrificed and their weights, albumin, AST, ALT, ALP, total-cholesterol, triglyceride, P, Ca, T4, E2, weight of a femur, ash content of the tibia, and area and thickness of trabecular bone were measured.
Results: Regarding the density of ALT, ALP, and estradiol from serum, the Lycii Fructus group was significantly decreased compared to the control group, and the density of phosphorous and calcium also decreased slightly. Moreover, albumin, triglyceride, and T4 showed an increasing propensity, but AST and total-cholesterol showed a decreasing propensity, but not significant. Regarding the variation of bone, femur weight and ash content of tibia, the Lycii Fructus group was increased compared to the control group but significance wasn’t shown. The Lycii Fructus group increased significantly over the control group in area and thickness of trabecular bone and osteoclast number.
Conclusions: From the results of the above study, Lycii Fructus should be effective for osteoporosis treatment and prevention.
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KEYWORD
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osteoporosis, ovariectomized rat, Lycii Fructus, trabecular, osteoclast
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